MR纹理分析鉴别诊断脑胶质母细胞瘤和单发转移瘤的价值

摘要

目的 探讨MR纹理分析鉴别脑胶质母细胞瘤和单发转移瘤的价值.方法 收集我院病理或临床证实为脑胶质母细胞瘤患者35例、脑单发转移瘤患者40例.所有患者均接受常规MR平扫及增强检查,包括T1 FLAIR、T2WI、T2 FLAIR、DWI及增强T1WI.采用MaZda软件于DWI及增强T1WI序列最大层面上手动勾画肿瘤ROI,提取病变的纹理特征.结果 脑胶质母细胞瘤和单发转移瘤的直方图纹理参数中增强T1WI的偏度,灰度共生矩阵参数中增强T1WI自相关、均值,DWI自关性差异有统计学意义.基于这些纹理参数构建多变量Logistic回归分析显示该模型的ROC曲线下面积为0.834.结论 纹理分析为鉴别脑胶质母细胞瘤和单发转移瘤,提供可靠、可以量化的客观依据.%Objective To explore the value of MR texture analysis in differential diagnosis of glioblastoma and solitary metastasis.Methods Thirty-five patients with brain glioblastomas and forty patients with brain metastases confirmed by pathology or clinic were enrolled.All patients underwent conventional MR scan and enhanced examination,including T1 FLAIR,T2WI,T2 FLAIR,DWI,and enhanced T1WI.Texture features of the lesions were extracted with MaZda software by manually drawing ROI on the maximum level of tumor delineation in DWI and enhanced T1WI.Results There were statistical differences between glioblastoma and solitary metastasis of enhanced T1WI skewness in the histogram class texture parameters,gray co-occurrence matrix parameters including enhanced T1WI image correlation,mean and DWI correlation.Logistic regression analysis showed the area under ROC curve of the model was 0.834.Conclusion Texture analysis can provide reliable and quantified objective basis for differential diagnosis of glioblastoma and solitary metastatic brain tumor.