Compounds derived from N - (2 - oxo - 1,2 dihydro - 3-pyridinyl) methyl - 1H indole - 3 - carboxamide,Inhibitors of Ezh2; Pharmaceutical composition containing; useful in Cancer Treatment selected from the group consisting of Brain glioblastomas (gliomas), leukemias and lymphomas.And disorders mediated by inhibition of Ezh2.

摘要

Compounds derived from N - [(2 - oxo - 1,2 dihydro - 3-pyridinyl) methyl] - 1H indole - 3 - carboxamide inhibitors of Ezh2; method to treat cancer selected from the group consisting of Brain gliomas),Glioblastomas, leukemias and lymphomas, among others; and its use for the treatment of a disorder mediated by inhibition of Ezh2.