Tbx20基因在心脏瓣膜发育中的作用

摘要

心脏瓣膜是心脏内不可缺少的重要且精巧的结构,心脏瓣膜的发育异常将导致心功能受损,瓣膜发育缺陷约占先天性心脏病的1/3.瓣膜形成是复杂的动态过程,包括谱系决定、细胞增殖、分化和迁移.本文将分别阐述Tbx20在心脏瓣膜不同发育时期的作用,并揭示Tbx20与其他瓣膜发育相关的信号通路及心内膜基因网络的相互关系,总结Tbx20在心脏瓣膜发育领域的最新进展.%Cardiac valves are highly organized yet delicate structures that ensure unidirectional blood flow through the cardiac chambers and large vessels.Disturbed development of cardiac valves can lead to aberrant heart formation and function which account for approximately one third of congenital heart diseases.The formation of cardiac valves is a dynamic process accomplished by a series of complex events including lineage determination and cell proliferation,differentiation and migration.This paper reviews current knowledge about the role of Tbx20 gene in the development of cardiac valves,which include functional diversities of Tbx20 at various stages of cardiac valve development,its interaction with other signaling pathways,and genetic network involved in endocardial development.