两个C19-二萜生物碱的结构鉴定和NMR信号归属

摘要

从剑川乌头(Aconitum handelianum)的根中分离得到两个C19-二萜生物碱:高展花乌头宁(homochasmanine,化合物1)和14-去苯甲酰大渡乌碱(14-debenzoylfranchetine,化合物2).采用1D和2D核磁共振(NMR)技术(包括1H NMR、13C NMR、DEPT、1H-1H COSY、HSQC、HMBC和NOESY)对其进行结构鉴定,完整归属了这两个化合物的1H和13C NMR信号.%Two C19-diterpenoid alkaloids,homochasmanine (compound 1) and 14-debenzoylfranchetine (compound 2),were isolated from the roots of Aconitum handelianum.Their structures were elucidated by one-dimensional and two-dimensional nuclear magnetic resonance (NMR) techniques,including 1H NMR,13C NMR,DEPT,1H-1H COSY,HSQC,HMBC and NOESY.The 1H and 13C NMR signals of the compounds were completely assigned.