研究表明，PI3K/AKT信号通路在非小细胞肺癌存在异常激活，对肿瘤细胞的增殖、凋亡、存活、耐药等起着重要的作用。顺铂是临床最常用一线化疗药物，但随着治疗的进展肿瘤对其耐药的现象越来越普遍，严重制约其临床效果。顺铂耐药是多种机制共同参与的复杂过程，其中PI3K/AKT通路或其组分持续被激活是非常重要的因素之一。本文对二者关系研究领域的进展作一综述。%Accumulating evidences indicate that aberrant activation of PI3K/AKT pathway in non-small cell lung cancer plays a vital role in tumor cell proliferation,apoptosis, and survival including drug resistance. Cisplatin as ifrst-line che-motherapy are in widespread clinical use in patients with non-small cell lung cancer, however, the development of cisplatin resistance signiifcantly impedes its clinic effcacy. Cisplatin resistance is a complicated process that various mechanisms par-ticipating in to interact, of which PI3K/AKT pathway keeping sustained activated is one of the most important reasons. hTis article reviewed the progress of research on the relationship between PI3K/AKT pathway and cisplatin resistance.
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