采用种子生长法,分别制备了金纳米星和金纳米双锥,利用透射电子显微镜、紫外-可见(UV-Vis)分光光度计等对样品进行了表征,并评价了金纳米星和金纳米双锥的光热转换性能、生物相容性以及体外光热治疗性能.结果表明,金纳米星和金纳米双锥的UV-Vis吸收峰位于808 nm和815 nm左右.在808 nm激光辐照下,光热转换效率分别为48.43%和53.68%.细胞实验表明,金纳米星和金纳米双锥具有良好的生物相容性.808 nm激光辐照5 min后,MCF-7细胞存活率分别降至22.54%和13.73%;且在同等条件下,金纳米双锥具有更加优异的光热治疗性能,是一种安全、高性能的肿瘤光热治疗用纳米探针材料.%Using seed-growth method,gold nanostars and gold nanobipyramids were synthesized,re-spectively,and they were characterized by transmission electron microscope and ultraviolet-visible (UV-Vis) spectrophotometer. Moreover,the photothermal conversion,biocompatibility and in vitro photothermal therapy(PTT) of gold nanostars and gold nanobipyramids were evaluated. The results show that the UV-Vis absorption peaks of gold nanostars and gold nanobipyramids are located at about 808 nm and 815 nm,and the photothermal conversion efficiency is calculated to be 48.43% and 53.68%. The cell experiments indicate that the gold nanostars and gold nanobipyramids have good biocompatibility,and the viabilities of MCF-7 cells incubate with gold nanostars and gold nano-bipyramids are decreased to be about 22.54% and 13.73%,after they are irradiated by 808 nm la-ser for 5 min, respectively. Furthermore, compared with the gold nanostars, the gold nanobipyra-mids have more excellent PTT performance,which could be good candidate as safe and high-efficient nanoprobe material for PTT in tumors.
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