microRNA在肝纤维化中的研究进展

摘要

微小RNA(microRNA,简称miRNA)是长约19～25个核苷酸的内源性非编码单链小RNA,其通过与mRNA 3'-端非翻译区(3'-untranslated region,3'-UTR)结合进行转录后水平的负性调控.miRNA通过调节肝星状细胞的活化、转分化、迁移、增殖和凋亡,在肝纤维化过程中发挥重要作用.不同miRNA在肝纤维化过程中发挥着不同的促(抗)纤维化作用,miRNA的作用已逐步引起科研工作者的重视.本文对miRNA在肝纤维化进程中的作用进行综述.%microRNA (miRNA) are endogenous single-stranded small non-coding RNA of 19～25 nucleotides that regulate gene expression at post transcription level through binding to the 3'-untranslated region (3'-UTR) of mRNA.miRNA are involved in the process of liver fibrosis by regulating the activation,differentiation,migration,proliferation and apoposis of hepatic stellate cell (HSC).Different miRNA play different roles on promoting (anti) fibrosis in liver fibrosis which attracted the attention of researchers gradually.In this paper,the roles of miRNA in the process of liver fibrosis were reviewed.