脑脊液核酸检测的研究进展

摘要

脑脊液(CSF)是与中枢神经系统关系最为密切的体液.与其他样本相比,CSF的成分能够直接反映中枢神经系统(CNS)的病变.CSF病原体核酸检测对CNS感染的诊断效果明显优于传统的检测方法.CSF中循环肿瘤DNA(ctDNA)非常有希望成为原发性脑肿瘤和转移性脑肿瘤的诊断和监测标志物.%The cerebrospinal fluid(CSF)is the most closely relatedbody fluidtocentral nervous system(CNS).Compared with other samples, CSF componentsare able to reflect the lesions of CNSmore directly.The detection of CSF pathogen nucleic acid is significantly better than the traditional detection method.Circulating tumor DNA(ctDNA)in CSF is very promising to be a diagnostic and monitoring marker for primary brain tumors and metastatic brain tumors.