骨转换标志物在骨质疏松症管理中的临床价值

摘要

Bone turnover is balanced with coupling of bone formation and resorption at various rates leading to continuous remodeling of bone.Osteoporosis diagnosis, which is nowadays generally made based on bone mineral density(BMD)measurements, suffers from certain limitations.Bone turnover markers (BTMs)can help improve osteoporosis detection.BTMs can provide information that is useful for the management of patients with osteoporosis,for assessing the possible causes of secondary osteoporosis and the correct dosage;they are also potentially useful as surrogate biomarkers for fracture.(Chin J Lab Med,2018, 41:333-336)%骨骼作为一种动态均衡的组织,通过骨吸收和骨形成不断相互制约达到骨质重塑的平衡状态.目前,基于骨密度测量对骨质疏松症进行诊断存在一定局限性.实验室检测骨转换标志物,可与骨密度测量相互补充,更好地对骨质疏松症患者进行评估和管理.临床可以根据骨转换标志物水平,鉴定骨转换水平较高和骨质丢失较快的患者,评估继发性骨质疏松症的可能原因并评估正确的用药剂量,因此骨转换标志物不仅可以辅助骨质疏松症的诊断,还可作为骨折的潜在标志物.(中华检验医学杂志,2018,41:333-336)