多肿瘤标志物蛋白芯片检测系统在消化道恶性肿瘤的临床应用价值

摘要

Objective To investigate the clinical application value of multi-tum or markers protein chip detective system in the diagnosis of digestive tractm alignancies or prognosis judgm ent.Methods The expression of twelve tum or markers in serum were detected by protien chip technology in 96 cases of malignant tum or of digestive tract cancer,87cases of benign digestive diseases,120 cases of healthy persons and 51 casts of postoperative malignant tum or of digestive tractcancer.Results The expression and the positive of twelve tum or markers in the malignant tum or group was significantly higher than that of the benign diseases group and healthy group,the differences were statistically significant(P＜0.05);The positive ratio(61.1％ - 82.3％ )of twelvecom bined detection was significantly higher than of single tum or maker (27.72 ％ - 70.5％ ) ; There w ere significant differences of malignant tum or of digestive trace cancer between preoperative patients and postoperative patients( P＜0.05 ) ;The expression of twelve tum orm arkers CA 199、CEA 、CA242、FER 、AFP、CA 125 and CA153 in digestive tract cncer was markedly stronger than others ( P＜0.05 ).Conclusion There was clinical application value of multi-tumorm arker protein chip detective system on general survey、 early diagnosis and prognosis judgment in malignant tum or of digestive trace cancer.%目的 研究多肿瘤标志物蛋白芯片检测系统在消化道恶性肿瘤的普查、诊断及预后判断的临床价值.方法 采用C-12蛋白芯片技术检测96例常见消化道恶性肿瘤患者组,87例消化道良性疾病患者组,120例健康查体者组血清中12项肿瘤标志物表达水平及阳性率,及51例消化道恶性肿瘤患者术后12项肿瘤标志物表达水平.结果 消化道恶性肿瘤组肿瘤标志物C-12检测结果及阳性率明显高于良性疾病组及健康查体组,差异有显著性(P＜0.05);12项联合检测阳性率(61.1%-82.3%)明显高于单项检测阳性率(27.72%-70.5%);消化道恶性肿瘤患者术前及部分患者术后C-12检测结果比较,差异也有显著性(P＜0.05);C-12中CA199、CEA、CA242、FER、AFP、CA125、CA153等7项在恶性消化道肿瘤中表达明显高于其余几项肿瘤标志物(P＜0.05).结论 多肿瘤标志物蛋白芯片检测系统用于恶性消化道肿瘤的普查、早期诊断及术后疗效观察,有一定的临床价值.