Objective To explore the diagnosis value and the changing level of neonatal urine trace albumin (MA) , alpha 1-micro globulin (αlM) and transfcrrin (TRU) to the newborn early renal damage. Methods Take the 24 h urine sample from 87 cases of suffocation newborn (mild choking 53 patients, severe suffocation 34 patients) and 40 caseswithout suffocation and severe infectious disease in the same period to check MA,alM and TRU; at the same time extract venous blood scrum to make the detection of crcatininc (Cr) and urea nitrogen (BUN). Results There is a significant increase of MA、α1M、TRU and blood Cr in the suffocation group than that of the control group,and still significant increases in severe suffocation group than that of the mild group,both has a very significant difference (P<0. 01) , but there is no statistical significance of blood BUN concentration in each group (P>0. 05). Conclusion The elevations of urine MA,a1M and TRU arc closely related to neonatal suffocation degree and renal injury,which arc effective indexes to monitor early renal damage in new-born babies.%目的 探讨窒息新生儿尿微量白蛋白(MA)、αl-微球蛋白(α1M)和转铁蛋白(TRU)水平的变化及对新生儿早期肾损伤的诊断价值.方法 取87例窒息新生儿(轻度窒息53例,重度窒息34例)及40例无窒息及严重感染性疾病的同期住院新生儿生后24 h尿液作MA、αlM、TRU检测;同时抽取静脉血检测血肌酐(Cr)、尿素氮(BUN).结果 窒息组尿MA、αlM、TRU及血Cr浓度异常率均较对照组明显升高,而重度窒息组尿MA、αlM、TRU及血Cr浓度异常率则较轻度组明显升高,均有极显著性差异(P<0.01),但血BUN浓度在各组间比较差异均无统计学意义(P>0.05).结论 尿MA、αlM、TRU升高与新生儿窒息程度及肾损伤密切相关,是窒息新生儿早期肾功能损伤监测的灵敏、有效的指标.
展开▼
