糖尿病性肾病早期诊断中尿微量蛋白和Ⅳ型胶原检测的应用研究

摘要

目的：探究尿微量蛋白联合Ⅳ型胶原检测在糖尿病性肾病早期诊断中的临床意义，并为该病的临床诊断提供价值性参考。方法选取我院于2010年3月-2013年2月就诊的80例非胰岛素依赖型糖尿病患者。根据患者是否并发肾病进行分组，其中研究组为并发肾病者，为42例，对照组为非并发肾病者，为38例。结果研究组尿微量蛋白和Ⅳ型胶原水平均高于对照组，且差异有统计学意义（P＜0．05）。结论尿微量蛋白和Ⅳ型胶原联合检测可作为糖尿病性肾病的早期诊断指标，对于糖尿病患者而言，应加强上述指标的监测。%Objective The purpose of the joint inquiry urine protein collagen typeⅣclinical significance in the early diagno-sis of diabetic nephropathy,and provide reference for the value of the clinical diagnosis of the disease.Methods In our hospital in March 2010-February 2013 were treated 80 cases of diabetes.Nephropathy according to whether the patient group,which is complicated by kidney disease study group,42 patients in the control group of non-diabetic nephropathy who was 38 cases.Re-sults The study group and urine protein levels were higherⅣ collagen,and the difference was statistically significant (P<0.05).Conclusion Urine protein and collagenⅣjoint detection can be used as an early diagnostic marker of diabetic nephropa-thy,diabetic patients should strengthen the monitoring of these indicators.