弥漫性轴索损伤患者血清 NSE 水平与 CT 表现及预后的相关性分析

摘要

Objective Explore the correlation between serum (Neuron Specific Enolase)NSE levels withCT Mani- festations and prognosis.in patients with diffuse axonal injury (DAI).Methods 86 patients with DAI and 16 healthy patients,serum NSE levels wre measured by ELISA.Statistics and analysis of changes in serum concentrations of NSE compared with CT manifestations and patient prognosis.Results Compared with healthy people,Diffuse axonal injury patients’NSE levels were significantly higher (P <0.01).Cisternal compressed,displacement>5 mm serum NSE lev-els were significantly higher than the displacement <5 mm patients (P <0.01);poor prognosis group’serum NSE lev-els were significantly higher than the good prognosis group (P <0.01 or P <0.05);patients in death group NSE con-centration continued to increase.Conclusion Serum NSE concentrations was significantly associated with degree of Cis-ternal compression and displacement in Patients with Diffuse axonal injury,and can be used as a biomarker to assess not only the severity of acute traumatic brain injury,but also help determine prognosis.%目的：探讨弥漫性轴索损伤（diffuse axonal injury DAI）患者血清神经元特异性烯醇化酶（Neuron Specific Enolase NSE）浓度与 CT 表现及患者预后的关系。方法DAI 患者86例和体检正常者16例，采用 ELISA 测定血清NSE 浓度，统计、分析弥漫性轴索损伤患者血清 NSE 浓度的变化与 CT 表现及患者预后的关系。结果弥漫性轴索损伤患者血清 NSE 浓度较健康体检正常者显著升高（P ＜0．01）。脑池受压、移位＞5 mm 患者血清 NSE 浓度显著高于移位＜5 mm 的患者（P ＜0．01）；预后不良组的血清 NSE 水平则明显高于预后良好组（P ＜O．01或 P ＜0．05）；死亡组病人 NSE 水平持续增高。结论弥漫性轴索损伤患者血清 NSE 浓度与脑池受压、移位程度显著相关，可作为一项生物标志物不仅可以评估急性脑外伤严重程度，还有助于判断预后。