联合检测血清IMA、hs-CRP与cTnI在急性冠状动脉综合征（ACS）的诊断价值

摘要

Objective To investigate the early diagnosis value of serum ischemia modified albumin(IMA)、high sen-sitive C-reactive protein(hsCRP)and cardiac troponin I (cTnI)in patients with acute coronary syndrome (ACS). Methods The 70 patients with coronary artery disease were divided into three groups:the stable angina pectoris (SAP) 25 cases,the unstable angina pectoris (UAP)28 cases,the acute myocardial infarction (AMI)22 cases,and select the healthy control group 25 subjects.The levels of four groups'IMA、hs-CRP and cTnI were detected and Compared.Re-sults The levels of three indicators of the AMI group were significantly increased (P<0.01)and the levels of IMA、hs-CRP of the UAP group were significantly higher than those the control group and the SAP group (P<0.01);Com-pared with the UAP group,the levels of hs-CRP and cTnI were significantly higher in AMI group(P<0.01),while the level of IMA there was no significantly difference(P>0.05);The levels of three indicators were no significantly differ-ence between SA group and control group (P>0.05).Conclusion IMA can be a sensitive diagnosis indicator of acute myocardial ischemia.Joint detection the levels of serum IMA、hsCRP、cTnI can be used to estimate the extent of myo-cardial inj ury,and play an important role in the diagnosis and treatment.%目的：探讨缺血修饰白蛋白（IMA）、超敏C反应蛋白（hs-CRP）和心肌肌钙蛋白 I（cTnI）在急性冠状动脉综合征（ACS）早期诊断中的价值。方法选取75例冠心病人：稳定性型心绞痛（SAP）25例，不稳定型心绞痛（UAP）28例，急性心肌梗死（AMI）22例，于入院后即刻取血测定其血清 IMA、hs-CRP及 cTnI的变化，并与25例健康者（对照组）进行比较。结果与对照组和 SAP组比较 AMI组三项指标水平有显著性差异（P＜0．01），UAP组的 IMA与 hs-CRP水平有显著性差异（P＜0．01）；与 UAP组比较 AMI组的 hs-CRP和 cTnI水平差异有显著性意义（P＜0．01），而IMA水平无统计学意义（P＞0．05）；SAP组与对照组比较三项指标水平无统计学意义（P＞0．05）。结论 IMA可作为急性心肌缺血的灵敏诊断指标；IMA、hs-CRP和 cTnI联合检测可评估 ACS患者心肌损伤程度，具有重要的诊断、指导治疗价值。