Clinical significance of combined detection of EASI lead and serum H-FABP, IMA in the diagnosis of coronary heart disease patients with myocardial ischemia

摘要

Objective: To explore the significance of combined detection of EASI lead and serum H-FABP, IMA in the diagnosis of coronary heart disease patients with myocardial ischemia. Methods: The 106 patients with myocardial ischemia of coronary heart disease treated in our hospital from March 2016 to June 2018 were taken as observation group and 106 healthy adults who were examined in our hospital at the same time were defined as control group. The abnormal rate of electrocardiogram (ECG), serum heart-type fatty acid binding protein (H-FABP) and ischemic modified albumin (IMA) in them, the diagnostic efficacy of single and combined detection in diagnosing myocardial ischemia of coronary heart disease and the area under receiver operating characteristic (ROC) curve of different joint detection were compared. Results: The abnormal rate of ECG, serum H-FABP and IMA levels in the observation group were higher than the control group. The specificity of EASI lead, serum H-FABP and IMA in the diagnosis of coronary heart disease patients with myocardial ischemia was different, the diagnostic specificity of H-FABP was higher than that of EASI lead and serum IMA. TThe sensitivity and negative predictive value of different parallel combined detection in diagnosing coronary heart disease were different. The specificity of different series of combined detection in the diagnosis of coronary heart disease was different. The areas under ROC curve of EASI lead+ H-FABP, H-FABP +IMA and EASI lead+ H-FABP +IMA were 0.713, 0.782 and 0.914, respectively, and the areas under ROC curve of series of combined detection were 0.709, 0.724 and 0.883, respectively. The area under the ROC curve of EASI lead+H-FABP+IMA was higher than that of EASI lead+H-FABP and H-FABP+IMA. Conclusions: The combination of EASI lead and serum H-FABP and IMA is of great significance in the diagnosis of coronary heart patients with myocardial ischemia. Combined application in clinical work can be considered.