CK-MB 及 cTnI 检测对手足口病患儿心肌损害的临床意义

摘要

目的：探讨血清肌酸激酶同工酶（CK-MB）及肌钙蛋白 I（cTnI）检测对手足口病（HFMD）患儿心肌损害的临床意义。方法选择2012年7月至2013年6月期间在我院住院的80例手足口病患儿为 HFMD 组；50例健康体检儿童为对照组，比较分析两组 CK-MB 及 cTnI 水平。结果手足口病患儿 CK-MB 水平为38．10±19．50 U／L，cT-nI 水平为0．2±0．07μg／L，均高于对照组（14．80±10．30 U／L，0．07±0．02μg／L），差异有统计学意义（P ＜0．05）。HFMD 组 CK-MB 检测阳性率56．3％（45／80），明显高于 cTnI 的33．8％（27／80），差异有统计学意义（P ＜0．05）。经积极治疗后 CK-MB 及 cTnI 水平均明显下降，较入院时比较，差异有统计学意义（P ＜0．05）。结论联合检测血清CK-MB 及 cTnI 对手足口病合并心肌损害的早期诊断具有重要临床意义。%Objective To explore the clinical significance of serum creatine kinase isoenzyme MB and troponin I for judging the myocardial injury of hand foot mouth disease (HFMD)children.Methods Choose 80 HFMD patients who were hospitalized with in our college from July 2012 to June 2014 as the observation group,and selected 50 healthy check-up children as the control group.We detected and comparatively analyzed the children of the two groups in crea-tine kinase isoenzyme and troponin I difference.Results HFMD group of creatine kinase isoenzyme and troponin I tese results are greatly higher than control group,and in HFMD group the creatine kinase isoenzyme and troponin I test re-sults had significantly reduced after taking effective treatment,and in HFMD group the positive rate of creatine kinase isoenzyme was great higher than the positive rate of troponin I,all the differences were statistically significant(P <0.05).Conclusion Combined detection of serum creatine kinase isoenzyme and troponin I have the important clinical meaning for the early clinical diagnosing HFMD and judging myocardial injury,it is worthy of the clinical promotion.