东北汉族人群抵抗素基因rs1862513(G/C)多态性与2型糖尿病相关性研究

摘要

目的 探讨东北汉族抵抗素基因rs1862513(G/C)位点与2型糖尿病发病及临床表型相关性.方法 应用连接酶反应分型法检测79例2型糖尿病患者及79例正常对照者rs1862513(G/C)多态性.结果 2型糖尿病组和对照组抵抗素rs1862513(G/C)位点基因型分布分别为GG49.5%、GC44.3%、CC6.2%和GG40.2%、GC47.4%、CC12.4%;等位基因频率分别为G型71.6%、C 28.4%和G型63.9%、C型36.1%,该位点的基因型分布和等位基因频率在两组间分布均无统计学意义(P值均>0.05).病例组CC基因型患者空腹血糖明显低于GG基因型患者(P值<0.05),体重指数、总胆固醇、甘油三酯、糖化血红蛋白、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、胰岛素以及胰岛素敏感指数等临床检测指标在rs1862513(G/C)三种基因型患者之间没有显著差异(P值均>0.05).结论 东北汉族人群抵抗素基因rs1862513(G/C)多态性与2型糖尿病发病无显著相关性,但与患者空腹血糖值相关.%Objective To explore the correlation of resistin gene rs1862513 (G/C) polymorphism with type 2 diabetes and its clinical phenotype in northeast Chinese Han population.Methods Seventy-nine type 2 diabetic patients and 79 normal controls were enrolled.The polymorphism of rs1862513 (G/C) was detected by ligase detection reaction.Results The genotype frequencies of rs1862513(G/C) in type 2 diabetes group and normal control group are GG 49.5%,GC44.3%,CC6.2% and GG 40.2%,GC 47.4%,CC 12.4% respectively.Allele frequency is G 63.9%,C 36.1% and G 71.6%,C 28.4% respectively.There was no difference of resistin gene polymorphism in disease group and normal control group (P>0.05).The level of fasting blood glucose in patients with genetype CC were significantly lower than that in patients with genetype GG (P<0.05).There wasno difference in body mass index,total cholesterol ,triglyceride,sglycated hemoglobin,high density lipoprotein cholesterol,low density lipoprotein cholesterol,insulin and insulin sensitive index(P>0.05)between the two patient groups.ConclusionWTBZ There is no significant correlation between resistin gene rs1862513(G/C) and type 2 diabetes in northeast Han population,but there is significant correlation with level of blood glucose.