晚期胰腺癌患者血清CA125,CA199水平与肝转移的关系

摘要

目的 分析晚期胰腺癌患者血清CEA,CA199水平与肝转移的关系,探讨胰腺癌肝转移的危险因素.方法 选取101例胰腺癌患者,主要根据有无肝转移分组,肝转移70例,无肝转移31例.采用化学发光免疫法对其血清标本中癌胚抗原(CEA)、糖抗原19-9 (CA19-9)、糖抗原125 (CA125)、糖抗原72-4 (CA72-4)、细胞角蛋白21-1(CY-FRA21-1)等项目进行检测.结果 血清CA19-9、CA125水平的增高与胰腺癌肝转移具有相关性(P＜0.05).结论 血清CA19-9、CA125水平的升高与胰腺癌肝转移有着一定相关性,是胰腺癌肝转移的危险因素.CA125升高(OS5.10个月vs10.87个月,P=0.005)、CA19-9≥1 000 U/mL(OS 5.13个月vs 8.53个月,P=0.003)与转移性胰腺癌不良预后相关.%Objective To explore the law of distribution of serum CA125 and CA199 in patients with liver metastases of pancreatic cancer,and to study the risk factors for liver metastases of pancreatic cancer.Methods CEA,CA19-9,CA125,CA72-4,CYFRA21-1 and other projects for testing in serum samples of 101 cases of pancreatic cancer patients with liver metastases were detected using chemiluminescence immunoassay.Mainly classified by liver metastasis,70 cases of liver metastasis,no liver metastasis were 31 cases.Results serum CA125,CA199 levels in patients with pancreatic cancer liver metastases is significantly increased (P＜0.05),which helps to find the metastasis and recurrence earlier than imaging examinations.Increase of serum CA19-9,CA125 level was correlated with liver metastases of pancreatic cancer (P＜0.05).Conclusion Increase of serum CA19-9,CA125 level has a certain relevance with liver metastases of pancreatic cancer,and it is risk factors for liver metastases of pancreatic cancer.Increase of serum CA125 (OS 5.10 month vs10.87month,P=0.005)、CA19-9≥1 000 U/mL(OS 5.13 month vs 8.53 month,P=0.003)are associated with the poor prognosis of patients with metastatic pancreatic cancer.