血清γ-谷氨酰转肽酶与2型糖尿病及并发糖尿病肾病的相关性研究

摘要

目的：探讨血清中γ-谷氨酰转肽酶（GGT）与单纯2型糖尿病（T2DM）及糖尿病性肾病（DN）的相关性。方法收集健康者（对照组）54例、2型糖尿病患者（T2DM组）73例和糖尿病肾病患者（DN组）73例的相关资料，并测定其血清中γ-谷氨酰转肽酶（GGT）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、超氧化物岐化酶（SOD）、谷胱甘肽（GSH）、8-羟基脱氧鸟苷（8-OHdG）、肌酐（Cre）、尿素氮（BUN）、尿酸（UA）、空腹血糖（FPG）含量以及24小时尿蛋白定量（24 h U-Pro），并进行比较分析。结果与健康对照组相比，T2DM组GGT、ALT、AST水平和FPG明显升高（P＜0．05），DN组的各项观察指标均明显高于健康对照组（P＜0．05）；与 T2DM组相比，DN组 ALT、AST水平无明显差异（P＞0．05），而 SOD、GSH明显降低（P＜0．05），其它指标均明显升高（P＜0．05）。T2DM患者血清 GGT水平与FPG、AST、ALT具有相关性，其中与 FPG关系最密切（r＝0．927）；DN 患者 GGT水平与所有检测指标均具有相关性，其中与24 h U-Pro关系最密切（r＝0．973）。结论血清 GGT与T2DM、DN有一定相关性，可能是导致这两种疾病发生的危险因素。%Objective To investigate the correlations between serum gamma glutamyltransferase (GGT)and type 2 diabetes mellitus (T2DM)complicated with diabetic nephropathy (DN).Methods The informationof healthy people (Control group)54 cases,type 2 diabetic mellitus patients (T2DMgroup)73 cases and diabetic nephropathy patients (DN group)73 cases was collected.The serum levels of gammaglutamyltranspeptidase (GGT),alanine aminotrans-ferase (ALT),aspartate aminotransferase (AST),superoxide dismutase (SOD),glutathione (GSH),8-hydroxy deoxy guanosine (8-OHdG),creatinine (CRE),blood urea nitrogen (BUN),uric acid (UA)and fasting plasma glucose (FPG) were detected and 24 h urinary protein (24 h U-Pro)was determinedquantitatively.Finally,thedata of three groups were analyzed.Results Compared with the Control group,the levels of GGT,ALT,AST and FPG were significantly higher in the T2DM group(P<0.05),and allthe observation indexes of DN group were significantly higher than those in Con-trol group;compared with the T2DM group,AST,ALT levels of DN groupwere not significantly different(P>0.05), while SOD and GSH were significantly lower(P<0.05),and other indexes were significantly higher(P<0.05).The level of GGT in T2DM group was correlated with FPG,AST and ALT,which is most closely related to FPG (r=0.927);The level of GGT in DNgroup was correlated with all the observation indexes,which is most closely related to 24h U-Pro FPG (r=0.973).Conclusion There is a certain correlation between serum GGT and T2DM complicated with DN,which may be the risk factors of these two diseases.