联合检测降钙素原、血沉、C-反应蛋白在膝关节置换术后感染的临床意义

摘要

目的：探讨血清降钙素原（ PCT）、血沉（ ESR）、C-反应蛋白（ CRP）联合定量检测在诊断膝关节置换术后感染的指导意义。方法选取2007年1月至2013年7月，新疆维吾尔族自治区人民医院骨科中心收治的21例膝关节置换术后感染的患者，同期膝关节置换术后非感染患者42例作为对照组。采用双抗体夹心免疫化学发光法（ ILMA）测定PCT水平，采用采用魏氏（ Westergren）法测定ESR水平，采用全自动免疫透视比浊法测定CRP水平。结果与膝关节置换术后非感染患者比较，膝关节置换术后感染患者的PCT、CRP、ESR显著高于非感染组，有统计学差异（χ²值分别为46.53、24.04、42.51，P均小于0.05）。结论 PCT、ESR及CRP的联合检测有助于膝关节置换术后感染的诊断，对及时合理应用抗菌药物及二次手术干预有重要的指导意义。%Objective To explore the value of the serum procalcitonin ( PCT ), blood sedimentation (ESR), and C-reactive protein (CRP) in combination with quantitative detection in the diagnosis of the infection after the knee replacement.Methods From January 2007 to July 2013, 21 cases of infection and 42 cases without infection ( as the control group ) after the knee replacement in the orthopaedic centre of Xinjiang Uygur autonomous region people′s hospital were selected.The PCT level was determined by double antibody sandwich immune chemiluminescence ( ILMA ), the ESR level was determined by Westergren method ( Westergren ), and the CRP level was determined by the automatic immune turbidimetric method.Results Compared with the patients without postoperative infection, the levels of PCT, CRP, and ESR of the patients with postoperative infection after TKA in with were significantly higher (χ² values were 46.53, 24.04, 42.51 respectively, P<0.05).Conclusion The combining detection of the PCT, ESR and CRP is helpful for the diagnosis of the infection after TKA, and it is important for the guidance of the timely and reasonable application of the antimicrobial agents and the second surgical intervention.