药物洗脱支架术后双联抗血小板药物应用二年与一年的比较

摘要

目的 对比置入药物洗脱支架(DES)后双联抗血小板治疗2年相比1年能否降低主要不良心血管事件.方法 入选2006年1月至2007年12月行DES的患者221例,按照双联抗血小板治疗1年和2年分为2组,初级终点为主要不良心血管事件(心源性死亡、非致命性心肌梗死、靶血管再次血运重建的联合终点).结果 截止至2009年12月的随访结果显示服用氯吡格雷1年组和2年组的主要不良心血管事件发生率分别为4.3%和4.7%,P=0.80.结论 置入DES术后延长双联抗血小板治疗时间至2年相比1年并未降低主要不良心血管事件.%Objective To compare the impact of 2 year versus 1 year dual antiplatelet therapy after drug-eluting stent implantation on occurrence rate of major adverse cardiac events (MACE). Methods A total of 221 patients successfully treated with DES between January 2006 and December 2007 were divided into two groups as one group with 1 year dual antiplatelet therapy (n = 157) and the other group on 2 years of treatment (n = 64). The primary endpoint included MACE and a composite of death, nonfatal myocardial infarction (MI), and target vessel revascularization (TVR). Results The rates of MACE were similar between the 1 year and 2 year treatment groups (4. 3％ and 4. 7％ respectively, P = 0. 80). Conclusions Two year dual antiplatelet therapy did not reduce MACE occurrence compared to 1 year dual antiplatelet therapy.