Objective To explore if any rules in electrocardiogram changes after transcatheter closure of perimembranous ventricular septal defects ( PMVSD ) . Methods We included all the 358 patients who have accepted transcatheter closure of PMVSD in our hospital between July 2006 to October 2014 and the electrocardiogram (ECG) done in hospital and during follow up in 1,3, 6 and 12 months after operation were all reviewed. Results No changes were found in heart rates and electrical axis during follow-up as compared to preclosure ECG. PR interval was shorter, the QRS duration and QT interval were longer than preclosure. Incidence rate of arrhythmia was 38. 0% ( 136/358 ) and incidence rate of serious arrhythmias ( including Ⅱ° or Ⅲ° atrioventricular block and complete left bundle branch block) was 5. 0%(18/358). Among the 180 patients who had ECG done in all follow up between the first 12 months post closure, the rates of new developed arrhythmias was 12. 8% ( 23/180 ) and severe arrhythmia was 0. 6%(1/180) during follow-up. Conclusions Incidence rate of serious arrhythmias after transcatheter closure of PMVSD is low and most patients have good clinical outcome.%目的：探讨膜周部室间隔缺损( PMVSD)患者行介入封堵术后心电图的变化规律。方法选取2006年7月至2014年10月青岛市市立医院东院区心内科行介入封堵的PMVSD患者358例,分析住院和来院复查(术后1、3、6、12个月)的心电图结果。结果 PMVSD患者行介入封堵术后随访期间与术前比较,电轴和心率无变化,PR间期缩短,QRS间期和QT间期都延长。358例患者术后心律失常发生率38.0%(136/358),而严重心律失常(即Ⅱ度或Ⅲ度房室传导阻滞、完全性左束支传导阻滞)发生率5.0%(18/358)；术后1~12个月随访到心电图的180例患者新出现心律失常的发生率12.8%(23/180),严重心律失常发生率0.6%(1/180)。结论介入封堵治疗PMVSD术后严重心律失常发生率低且转归好,是一项创伤小、恢复快、疗效可靠的治疗方法,值得在临床上推广应用。
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