Objective To explore the relationship between plasma visfatin and matrix metalloproteinase - 9 (MMP- 9) in patients (pts) with coronary heart disease (CHD). Methods Eighty pts with CHD diagnosed by angiography without diabetes mellitus were divided into acute coronary syndrome(ACS) group (n= 50) and stable angina pectoris(SAP) group (n= 30),and 30 healthy subjects as controls. Pts with CHD were divided into one vessel disease subgroup (n= 26), two vessels disease subgroup (n = 27), and three vessels disease subgroup (n=27). The levels of plasma visfatin and MMP - 9 were determinated by ELISA method. Results The concentrations of plasma visfatin and MMP - 9 in CHD group were significantly higher than that in control group(P＜0.05). The concentrations of plasma visfatin and MMP -9 in ACS group were higher than that in SAP group(P＜0.05). The concentrations of plasma visfatin and MMP - 9 in three vessels disease subgroup were higher than that in two vessel disease subgroup(P＜0.05). The concentrations of plasma visfatin and MMP - 9 in two vessels disease group were higher than that in one vessel disease subgroup (P＜0. 05). The concentrations of plasma visfatin and MMP - 9 in one vessels disease group were higher than that in control group(P＜0.05). The level of plasma visfatin was positively corrected with MMP - 9 (r= 0. 763, P＜0.05). Conclusion The level of plasma visfatin and MMP - 9 were correlated with CHD.%目的 探讨内脂素及基质金属蛋白酶-9(MMP-9)在冠心病(CHD)中的相关性及临床意义.方法 选择80例经冠脉造影确诊为冠心病并排除糖尿病的患者和30名健康体检者.冠心病诊断标准为冠状动脉至少一支血管狭窄程度≥50%.将80例CHD患者分为急性冠脉综合征(ACS)组(50例)与稳定型心绞痛(SAP)组(30例).根据冠脉造影将患者分为单支病变组(26例)、双支病变组(27例)、三支病变组(27例).以酶联免疫吸附试验法检测80例患者及30例健康对照者血浆内脂素和MMP-9水平.结果 ACS与稳定型心绞痛患者血浆内脂素和MMP-9显著高于对照组(P<0.05),ACS患者血浆内脂素和MMP-9高于与稳定型心绞痛(P<0.05),三支病变组内脂素与MMP-9高于双支病变组(P<0.05),双支病变组高于单支病变组(P<0.05),单支病变组高于对照组(P<0.05).内脂素水平与MMP-9水平显著正相关(r=-0.763, P<0.05).结论 内脂素、MMP-9与冠心病密切相关,且对冠心病的诊断及预测冠状动脉病变严重程度具有重要临床意义.
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