重组人脑利钠肽治疗急性ST段抬高型心肌梗死合并心力衰竭的疗效观察

摘要

目的：评价重组人脑利钠肽(rhBNP)治疗急性 ST段抬高型心肌梗死(STEMI)合并心力衰竭的疗效及其不良反应。方法46例 STEMI合并心力衰竭患者随机分成两组。治疗组23例，在常规药物治疗的基础上加用 rhBNP 治疗；对照组23例，仅采用常规治疗。观察两组患者用药前后生命体征、呼吸困难程度、相关血流动力学指标以及脑钠肽(BNP)的变化。结果治疗后两组血压、心率、心功能分级、左室射血分数、尿量及BNP差异有统计学意义(P<0.05)。结论常规治疗基础上联用rhBNP治疗STEMI合并心力衰竭的疗效显著，安全可行。%Objective To assess the effect and adverse reactions of recombinant human brain natriuretic peptide(rhBNP)on ST segment elevation acute myocardial infarction (STEMI)patients with heart failure.Methods Forty six STEMI patients with heart failure were randomly divided into two groups:Control group (n=23)treated with traditional therapy,and treatment group (n=23)treated with traditional therapy and rhBNP.Hemodynamics data were observed before and after the treatment.Results After the treatment, there were significant differences in clinical performance (including symptoms and signs),functional class,left ventricular ejection fraction,and urine volume (average urine volume per hour )between control group and treatment group (P<0.05).Conclusion rhB-NP was a valuable adj uvant to traditional therapy in treatment of STEMI with heart failure and low incidence of adverse reactions.