进展性脑梗死外周血炎症免疫因子mRNA表达的临床研究

摘要

目的：探讨急性进展性脑梗死与炎症免疫因子基因表达的关系。方法对38例进展性脑梗死、90例非进展性脑梗死患者进行白介素6(IL 6)、白介素10(IL 10)、肿瘤坏死因子α(TNF α)mRNA表达测定。结果进展性脑梗死组IL 6、IL 10mRNA表达水平明显异常于非进展性脑梗死组(P<0.05)。IL 6mRNA表达水平是脑梗死进展的危险因素。结论外周血炎症免疫因子基因表达水平的异常与进展性脑卒中密切相关，可能参与进展性脑梗死的发病过程中。%Objective To investigate the relationship of progressive cerebral infarction (PCI)with serum inflammatory immune factors gene expression.Methods Thirty eight patients with PCI and 90 patients with stabile cerebral infarction were enrol ed.The levels of interleukin(IL) 6,IL 10,tumor necrosis factor α(TNF α)gene expression were measured.Results The levels of IL 6,IL 10 mRNA expression had more significant difference in patients with PCI than that in stabile cerebral infarction.Gene expression of IL 10 was the risk factor in PCI.Conclusion The abnormal levels of inflammatory immune factors mRNA expression may be closely relat-ed to PCI.They may play an important role in progressive ischemic stroke.