血液透析患者血浆FGF23水平与颈动脉粥样硬化关系的研究

摘要

目的:探讨血液透析(HD)患者血浆成纤维细胞生长因子(FGF23)浓度与颈动脉粥样硬化程度的关系.方法:采用酶联免疫法(ELISA)检测186例维持性血透患者血浆FGF23浓度,高分辨二维超声技术测量颈动脉内膜-中层厚度(IMT)及粥样硬化斑块.结果:IMT增厚组及颈动脉斑块组血浆FGF23浓度明显高于颈动脉正常组(3.12±0.23 vs 2.67±0.21,P＜0.01).FGF23浓度与IMT存在显著正相关(r=0.496 P=0.000),多因素逐步回归分析,FGF23浓度是血液透析患者IMT增加的独立危险因素.结论:血液透析患者动脉粥样硬化病变与FGF23有关,FGF23在血液透析患者颈动脉粥样硬化的发生发展中起着重要作用.%Objective : To investigate the association between plasma fibroblast growth factor - 23( FGF23 ) and carotid atherosclerosis in hemodialysis( HD ) patients.Methods : 186 HD patients were involved in the study.plasma FGF23 concentrations were determined by ELISA.Carotid artery intima - media thickness and atherosclerotic plaques were determined by high resolution B mode ultrasonography.Results : Log plasma FGF23 were higher in patients with plaques in CCA than patients free of plaques ( 3.12 ±0.23 vs 2.67 ±0.21 P ＜ 0.01 ).Significant correlation was recorder between log FGF23 and IMT( r = 0.496 P = 0.000 ).In multiple regression analysis, a high log FGF23 concentration was a significant independent risk factor of an increased IMT.Conclusion :In HD patients, atherosclerosis was correlated with plasma FGF23 concentration, plasma FCF23 played an important role in development of carotid atherosclerosis.