不同证型慢性重型肝炎患者血浆内毒素水平与Child-Pugh评分的相关性分析

摘要

Objective:To explore correlation between endotoxin level in plasma and Child-Pugh score in patients with chronic severe hepatitis (CSH)in different pattern of Traditional Chinese Medicine (TCM).Methods:100 hospitalized cases with CSH from department of liver disease were divided into five groups according to the TCM pattern identification.Normal control group was set up with 20 healthy adults.Child-Pugh score and endotoxin in plasma were calculated and tested respectively in each group and then statistic analysis were made.Results:Endotoxin was not detected in 20 healthy adults.The correlation coefficient in the pattern of heat toxin entering blood was largest and its correlation coefficient was r =0.751 (P ＜ 0.01).The following pattern was heat toxin flaming and its correlation coefficient was r =0.481 (P ＜ 0.01).The remaining three groups also had certain correlation,but the correlation coefficient were slightly less than those of the heat toxin entering blood group and heat toxin flaming group.Conclusion:There was a positive correlation relationship between Endotoxin level and Child-Pugh score.With higher endotoxin level,Child-Pugh score was higher and the mortality was also higher in patients with different TCM patterns.%目的:探究不同证型CSH患者血浆内毒素水平与Child-Pugh评分之间的相关性.方法:选择在我院肝病科住院的CSH患者100例,按中医辨证分型标准分为5个组,另设一组健康成年人20例作为正常对照,计算患者Child-Pugh评分分值和检测各组患者血浆内毒素水平,并进行统计分析.结果:20例健康成年人未检出内毒素;5个证型中热毒入营(血)证相关系数最大,即相关系数r =0.751(P＜0.01),其次是热毒炽盛证,相关系数r=0.481(P＜0.01),其余3证型也存在一定的相关性,但相关系数要略低于前两证.结论:不同中医证型CSH患者内毒素水平与Child-Pugh评分分值之间存在正相关关系;内毒素水平越高者,其Child-Pugh评分越高、死亡率亦越高.