当飞利肝宁联合甘草酸二胺治疗药物性肝损伤临床观察

摘要

Objective:To observe the curative effect of treating drug-induced liver injury with Dangfei liganning capsule combined Diammonium Glycyrrhizina.Methods:65 patients with drug-induced liver injury were randomly divided into observation group (35 cases) and control group (30 cases).The observation group was treated with Dangfei Liganning capsule combined Diammonium Glycyrrhizina.The control group was treated with Polyene Phosphatidylcholine Capsules.The course of observation was 4 weeks.Results:After treatment,alanine aminotransferase (ALT),aspartate aminotransferase (AST),Gu An transferase (GGT),total bilirubin (TBil) were significantly decreased in the two groups (P ＜ 0.01).The curative effect of the observation group was more obvious than that of the control group (P ＜ 0.05).After treatment,the clinical symptoms and total effective rate of the observation group were better than those of the control group (P ＜ 0.05).The observation group had less adverse reactions(P ＜0.05).Conclusion:Dangfei Liganning capsule combined Diammonium Glycyrrhizina can improve the clinical curative effect safely.%目的:观察当飞利肝宁联合甘草酸二胺治疗药物性肝损伤的疗效.方法:将65例药物性肝损伤患者随机分为观察组35例和对照组30例.观察组患者口服当飞利肝宁胶囊和甘草酸二胺胶囊;对照组患者口服多烯磷脂酰胆碱胶囊,疗程均为4周.结果:治疗后两组患者的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、总胆红素(TBil)均明显下降与治疗前比较(P＜0.01),观察组比对照组下降更明显(P＜0.05);治疗后观察组患者临床症状改善、总有效率优于对照组,不良反应少,差异有统计学意义(P＜0.05).结论:当飞利肝宁和甘草酸二胺胶囊联合应用,可提高患者临床疗效,且用药较安全.