目的：探讨中药保留灌肠治疗放射性直肠炎最优技术方案(包括给药温度、滴注时间、药量、插管深度)。方法采用正交试验设计方法，将63例放射性直肠炎患者随机分为9组，按照不同的试验条件灌肠给药。疗程均为6周。分别以治疗后中医证候积分、放射损伤疗效评定结果、体力状况评分为效应指标，对正交试验结果进行方差分析，得出中药保留灌肠治疗放射性直肠炎最优技术方案。结果给药温度(39±0.5)℃、滴注时间30 min、药量100 mL、插管深度20 cm为中药保留灌肠最优技术方案。结论本研究所得放射性直肠炎灌肠条件的优化方案合理可行。%Objective To explore the optimal method of treatment for radiation proctitis by keeping coloclysis with traditional Chinese medicine (TCM), including administation temperature, infusion time, dosage and catheter depth. Methods The orthogonal experimental design was adopted. Sixty-three patients with radiation proctitis were randomly divided into 9 groups, and they were under enema for 6 weeks according to different test conditions. TCM syndrome score, radiation injury effect and Karnofsky scores were set as evaluation indexes. An orthogonal design and analysis of variance were conducted for optimization. The best technical schemes for traditional Chinese herb in treating radiation proctitis were obtained. Results The obtained optimum methods are:drug temperature of (39±0.5)℃, infusion time of 30 minutes, dosage of 100 mL, catheter depth of 20 cm. Conclusion The optimal scheme of enema for the treatment of radiation proctitis is reasonable and feasible.
展开▼
