基于文献的绝经综合征中医证候特征研究

摘要

目的 研究绝经综合征中医证候特征分布规律,为临床治疗及后续研究提供依据.方法 计算机检索中国知识资源总库(CNKI)、中文科技期刊数据库(重庆维普)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)、中国中医药数据库(TCMDS)1983年6月-2013年6月绝经综合征相关文献,将原始数据量化后录入计算机,建立相关数据库,采用聚类分析、因子分析、频数优势法相结合的方式进行数据分析.结果 纳入文献270篇,涉及730例患者,包含证候42种、症状73种.提取频数分布前9位的证候四诊信息进行聚类分析,得到5类基本证型:肝肾阴虚证、肝郁气滞证、心肾不交证、心脾两虚证、脾肾阳虚证;因子分析结合频数优势法提取各证型核心症状,得到各证候的辨证要点.结论 本研究采用3种方法并结合相关专家意见,初步建立了绝经综合征证候诊断方案,可为临床及后续研究提供参考.%Objective To study distribution rules of TCM syndrome characteristics of menopausal syndrome; To provide references for clinical treatment and further study.Methods The articles related to menopausal syndrome in CNKI, VIP, Wanfang Data, CBM and TCMDS during Jun. 1983 to Jun. 2013 were retrieved and analyzed. The original data were input into computer and established the menopausal syndrome literature database. Methods of cluster analysis, factor analysis, and frequency analysis were combined to conduct statistical analysis.Results A total of 270 articles and 730 patients were included in the analysis, including 42 syndromes and 73 symptoms. The four diagnostic information of top 9 syndromes was analyzed by clustering and 5 kinds of basic syndrome types were obtained, including liver and kidney yin deficiency, liver depression, heart-kidney disharmony, heart and spleen deficiency, and spleen and kidney yang deficiency; the core symptoms of each syndrome were extracted by factor analysis and frequency dominance method, and the main points of syndrome differentiations were initially established. Conclusion Three methods combined with relevant expert advice were used to initially establish the syndrome diagnosis of menopause syndrome, which can lay a solid foundation for further study.