Objective To evaluate the early signals and associated symptoms of septic shock in neonates, so as to provide reference for early diagnosis and treatment.Methods Thirty-one neonates who were hospitalized and diagnosed as septic shock in a hospital between January 2001 to March 2009 were analysed retrospectively.Results The early manifestations of neonatal septic shock were milk refusal or reduced milk acceptance (29 cases, 93.55 ％), lassitude (24 cases, 77.42 ％ ), irritability (20 cases, 64.52 ％), repeated cyanosis(11 cases, 35.48 ％); Septic shock progressed rapidly, most neonates (27 cases, 87.10％) developed shock within 24 hours after onset.The mortality was high (19 cases, 61.29％) , 14 of 17 (82.35％) neonates died during the period of 2001 -2005; 5 of 14 neonates (35.71％) died between 2006- 2009, there was significant difference between the two stages (x2 =77.04, P = 0.008).Conclusion The early signals of neonatal septic shock are milk refusal or reduction of milk acceptance,lassitude, irritability, repeated cyanosis.Timely recognition and proper treatment can save neonatal life%目的 探讨新生儿感染性休克的早期信号与伴随症状,为临床早诊断、早治疗提供参考.方法 回顾性分析某院2001年1月-2009年3月住院且符合感染性休克诊断标准的31例患儿资料.结果 拒乳或吸乳量减少(29例,93.55%)、精神差(24例,77.42%)、烦躁(20例,64.52%)与反复青紫(11例,35.48%)为新生儿感染性休克的早期表现;出现早期表现后,病情进展迅速,大部分(27例,87.10%)在发病24 h内即进入休克期.新生儿感染性休克病死率(19例,61.29%)高,2001-2005年,17例新生儿病死14例(82.35%);2006-2009年,14例新生儿病死5例(35.71%),两阶段比较,差异有高度显著性(X2=77.04,P:0.008).结论 拒乳或吸乳量减少、精神差、烦躁及反复青紫是新生儿感染性休克的早期信号.及时识别和恰当的治疗可以挽救新生儿的生命.
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