恶性血液病患者合并产气荚膜梭菌血症1例病例报告并文献回顾

摘要

感染是血液病患者病死率高于正常人的重要原因,且发热经常是其唯一指征.产气荚膜梭菌是梭菌属的革兰阳性厌氧杆菌,属于肠道正常菌群,正常情况下不致病.但是当人体免疫力低下或受到饮食、药物、环境等因素影响导致肠道发生菌群失调,可导致产气荚膜梭菌入血,引起菌血症.目前,由该菌感染导致恶性血液病伴中性粒细胞缺乏患者发生菌血症的病例国内尚未见报道,此文报告1例恶性血液病患者合并产气荚膜梭菌血流感染病例的诊断和治疗经过,以期为此病的诊治提供依据.%Infection is an important cause of higher mortality in patients with hematological diseases than healthy people, and fever is often the only indication of the disease.Clostridium perfringens(C.perfringens)is a grampositive anaerobic bacillus of the Clostridiumgenus, it belongs to the normal flora of the intestinal tract and is not pathogenic in normal condition.However, when intestinal flora is imbalanced due to low hypoimmunity of human body or influenced by such factors as diet, medicine, environment and other factors, it can enter the blood and cause bacteremia.At present, it has never been reported that bacteremia was caused by C.perfringens in patients with malignant hematological diseases accompanied by neutropenia, this article reported the diagnosis and treatment of C. perfringens bloodstream in one patient with malignant hematopathy, so as to provide basis for diagnosis and treatment of the disease.