Objective To analyze the pattern of antibiotic resistance in 1 073 strains of Pseudomonas aeruginosa in People's Hospital of Xinjiang Autonomous Region during 2003-2007. Methods Automated microbe analyzer (VITEK32) was used to analyze antibiotic susceptibility by means of GNS drug sensitivity card and Kirty-Bauer method. Results In recent five years, 1 073 strains of P. aeruginosa were isolated from respiratory specimens, most of which were from ICU, respiratory ICU and surgery ICU (57.8%). Among the 16 antibiotics tested, these strains showed the lowest resistance (17.0%) to cefoperazone-sulbactam, followed by meropenem (18.5%), amikacin (19.6%), imipenem (24.2%), cefepime (25.7%), piperacillin-tazobactam (35.7%) and ceftazidime (36.7%). Although the resistance to cefoperazone-sulbactam and ceftazidime was relatively lower, the prevalence of intermediate strains was relatively higher, 15.2% and 12.5% respectively. Conclusions The antibiotic resistance surveillance Results of five consecutive years indicate that P. aeruginosa was one of the most common pathogens in this hospital associated with serious issue of antibiotic resistance.%目的 分析2003-2007年我院1 073株铜绿假单胞菌对抗菌药物的耐药情况.方法 采用全自动微生物分析仪VITEK32进行细菌鉴定,用GNS药敏卡及Kirty-Bauer法进行药敏试验.结果 5年来,1 073株铜绿假单胞菌以下呼吸道标本中最为常见(61.4%).以ICU、呼吸科ICU、外科ICU检出率最高(57.8%).对16种抗菌药物耐药率较低的有头孢哌酮-舒巴坦(17.0%)、美罗培南(18.5%)、阿米卡星(19.6%)、亚胺培南(24.2%)、头孢吡肟(25.7%)、哌拉西林-他唑巴坦(35.7%)和头孢他啶(36.7%).虽然头孢哌酮-舒巴坦、头孢他啶的耐药率较低但中介率较高,分别达15.2%、12.5%,应引起临床医师高度重视.结论 连续5年回顾性分析,铜绿假单胞菌是我院医院感染的主要病原菌,对16种抗菌药物的耐药性相当严重,且常呈多重耐药,给临床抗感染治疗带来很大的困难.应重视耐药菌株监测,对临床合理用药有指导作用和实用价值.
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