Objective To evaluate the clinical efficacy of antibacterial agents in the sequential therapy of 38 cases of community-acquired pneumonia due to Legionella pneumophila and provide supporting data for the treatment of Legionella pneumonia. Methods The clinical data and outcomes of the 38 patients following sequential therapy with levofloxacin and macrolides were reviewed retrospectively. Results All the 38 patients were cured after the diagnosis was confirmed as community-acquired pneumonia due to Legionella pneumophila. The temperature was normalized 2. 2 ± 1. 1 days after antimicrobial therapy. No serious adverse reaction was identified. The total duration of treatment in the hospital was 23. 5 + 13. 5 days. Conclusions Sequential therapy with levofloxacin and macrolides is safe and effective for the community- acquired pneumonia caused by Legionella pneumophila.%目的 探讨社区获得性嗜肺军团菌肺炎抗菌治疗的疗效,为临床治疗嗜肺军团菌感染提供依据.方法 调查38例确诊嗜肺军团菌肺炎患者使用左氧氟沙星联合大环内酯类抗生素治疗后的转归及临床特点,分析联合用药、疗程、不良反应等情况.结果38例患者治疗后痊愈,给药后(2.2±1.1)d体温降为正常,总住院时间(23.5±13.5)d,治疗后未出现严重不良反应.结论选用左氧氟沙星联合大环内酯类抗生素序贯治疗社区获得性嗜肺军团菌肺炎,疗效确切,不良反应少.
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