丙烯酰胺中毒Ola和6J鼠小脑Purkinje细胞的病理改变

摘要

Objective　To observe the differential pathological changes in Purkinje cells of the cerebellum in Ola mice and 6J mice after acrylamide intoxication. Methods　Purkinje cells were studied by light microscope and electron microscope. Results　Under light microscope,Purkinje cells in 6J mice were densely stained and irregular in cell shape.Under electron microscope,parts of the plasma membrane projection containing some smooth tubular endoplasmic reticula were found occasionally,and the membrane became split and thickened.These abnormal changes were not found in Ola mice. Conclusion　Acrylamide intoxication may induce pathological changes in Purkinje cells of 6J mice which may be the pathological basis of ataxia.%目的　观察丙烯酰胺(ACR)中毒后Ola和6J鼠小脑的不同病理改变。方法　采用病理学技术对小脑Purkinje细胞进行光镜和电镜定性分析。结果　光镜下小脑整个Purkinje细胞深染,形态不规则；电镜下偶见胞膜限局性膨出,内含一些管状滑面内质网,在突起的表面部分胞膜分层、变厚。上述改变仅见于6J鼠，而Ola鼠未见异常变化。结论　丙烯酰胺中毒导致6J鼠小脑Purkinje细胞病理改变，这种变化可能是产生共济失调的病理基础。