HIF-1α、MVD及EGFR表达对鼻内翻性乳头状瘤恶变的诊断意义及紫杉醇干预效果分析

摘要

Objective:To explore the significance of the expression of HIF-1α,MVD and EGFR on diagnostic of nasal inverted papilloma and the clinical effect of taxol .Methods:The expression of HIF-1α,MVD and EGFR were detected by immunohistochemistry in nasal inverted papilloma .Results:The expression of HIF-1α,MVD and EGFR were enhanced with the degree of atypical hyperplasia in epithelium.The research also showed that the expression of HIF-1α,MVD and EGFR were increased dramatically in severe atypical hyperplasia with a significant statistical differences ( P<0.01 ) .The expression of EGFR and MVD showed a positive correlation with HIF-1α.The administration of Taxol alleviated the enhanced expression of HIF-1α, MVD and EGFR with a significant statistical difference(P<0.01),but with on statistical difference with moderately severe tissue (P>0.05).Conclusion:HIF-1α,MVD and EGFR are involved in the pathogenesis and deteriorate of nasal inverted papilloma and can be taken as biomarkers for the diagnosis of the dete -rioration of nasal inverted papilloma .%目的:分析HIF-1α、MVD及EGFR的表达对鼻内翻性乳头状瘤恶变不同阶段的诊断意义及紫杉醇的临床效果.方法:采用免疫组织化学方法检测并定量分析鼻内翻性乳头状瘤、轻度及中重度不典型增生状和恶变组织中HIF-1α、MVD及EGFR的表达情况及三者的相关性,并分析紫杉醇对恶变组织中上述分子的改善作用. 结果:HIF-1α、MVD及EGFR的表达随增生及恶化程度的加剧而增强,且鼻内翻性乳头状瘤、轻度及中重度不典型增生状组织中HIF-1α、MVD及EGFR的表达具有显著的统计学差异性( P<0.01 ) ,HIF-1α与MVD及EGFR表达呈正相关性. 紫杉醇可显著改善恶变组织中HIF-1α、MVD及EGFR的表达,且紫杉醇治疗后与中重度不典型增生状组织表达无显著的统计学差异性( P>0.05 ). 结论:HIF-1α、MVD及EGFR参与了鼻内翻性乳头状瘤的发生、增生及恶化过程,可以作为临床诊断鼻内翻性乳头状瘤增生及恶化的标志物.