盐酸坦索罗辛对慢性前列腺炎患者血清炎症因子的影响

摘要

目的:探讨盐酸坦索罗辛对慢性前列腺炎患者血清炎症因子的影响.方法:选取2014年1月至2015年12月我院收治的86例慢性前列腺炎患者作为研究对象.随机分为观察组和对照组,每组各43例.对照组采用左氧氟沙星胶囊治疗,观察组在对照组的基础上采用盐酸坦索罗辛胶囊治疗.观察比较两组的白细胞计数、分泌型免疫球蛋白A、炎症因子水平和尿动力学指标.结果:治疗后,两组患者的白细胞数较治疗前显著降低(P＜0.05),且观察组的白细胞数水平低于对照组,差异有统计学意义(P＜0.05).治疗后,两组患者的SIgA较治疗前显著降低(P＜0.05),且观察组的SIgA水平低于对照组,差异有统计学意义(P＜0.05).治疗后,两组患者的IL-8和TNF-α均比治疗前显著降低(P＜0.05),且观察组的指标水平低于对照组,差异有统计学意义(P＜0.05).治疗后,观察组的MFR显著高于对照组,RVU显著低于对照组,差异均有统计学意义(P＜0.05).结论:盐酸坦索罗辛治疗慢性前列腺炎的效果显著,能明显降低炎症因子水平,改善患者的尿动力学,提高患者免疫力.%Objectives:To explore the effect of tamsulosin combined with levofloxacin on the serum inflammatory factor of patients with chronic prostatitis.Methods:86 patients with chronic prostatitis who received treatment in our hospital from January 2014 to December 2015 were selected as the research object,which were randomly divided into observation group and control group,with 43 cases in each group.The control group was given Levofloxacin Capsule for treatment,and the observation group was treated with Tamsulosin Capsules and Levofloxacin Capsule.The white blood cell count,secretory immunoglobulin A,levels of inflammatory cytokines and urodynamic indices in two groups were compared.Results:After treatment,the number of white blood cells of both group was significantly decreased than that before treatment (P ＜ 0.05),and that in the observation group was lower than that in the control group,with statistically significant difference (P ＜ 0.05).After treatment,the SIgA decreased significantly in both groups than that before treatment (P ＜ 0.05),and that in the observation group was lower than that in control group,with statistically significant difference (P ＜ 0.05).After treatment,the IL-8 and TNF-α in the two groups were significantly lowered than these before treatment (P ＜ 0.05),and the level of indexes in the observation group was all lower than these in the control group,with statistically significant difference (P ＜ 0.05).After treatment,the MFR in observation group was significantly higher than that in control group,and the RVU in observation group was significantly lower than that in control group,with statistically significant difference (P ＜ 0.05).Conclusion:Tamsulosin is with significant curative effect in the treatment of chronic prostatitis,which can significantly reduce the level of inflammatory factors and improve the patients' urodynamic index and immunity.