血清降钙素原浓度在急性胆管炎严重程度分级中的作用

摘要

目的 探讨血清降钙素原(PCT)浓度在急性胆管炎严重程度分级中的应用及其临床意义.方法 回顾性分析2012年5月至2013年11月东阳市人民医院收治的147例急性胆管炎患者临床资料.结果 本组147例患者轻、中、重度胆管炎血清PCT浓度分别为(165.63±32.67) pg/ml、(348.97±45.78) pg/ml、(758.91±28.94) pg/ml.重度胆管炎PCT浓度明显高于中度胆管炎PCT浓度(P＜0.05).中度胆管炎PCT浓度高于轻度胆管炎PCT浓度(P＜0.05).不同程度胆管炎血培养前三位病原菌亚组间PCT血浓度差异均无统计学意义(P＞0.05).结论 血清PCT在急性胆管炎中明显升高,是评价急性胆管炎严重程度的有效参数.%Objective To evaluate the role of procalcitonin in patients with different severity grades of acute cholangitis (AC).Methods A retrospective study was carried out on 147 patients with different severity grades of AC who were treated from May 2012 to November 2013 at the Dongyang People's Hospital.Results Of 147 patients,the PCT concentrations were (165.63 ± 32.67) pg/ml,(348.97 ± 45.78) pg/ml,(758.91 ± 28.94) pg/ml for patients with mild,moderate and severe AC respectively.The PCT concentrations were significantly higher in patients with severe AC than those with moderate AC (P ＜ 0.05),and also in patients with moderate AC than those with mild AC (P ＜ 0.05).The top three bacteria obtained from blood culture from the different severity grades of AC showed no significant diferences (P ＞ 0.05).Conclusion Serum PCT concentrations were elevated in patients with AC and it may be used as a parameter to assess the severity of AC.