Objective To determine the association of serum level of high sensitivity C-reactive protein (hs-CRP) and different components of metabolic syndrome. Methods The same epidemiological questionnaire was used to investigate the demographic data, disease status, lifestyle information and making medical examination. The blood glucose, plasma total cholesterol (TC ) , triglyceride ( TG) , high density lipoprolein cholesterol ( HDL-c) , uric acid, creatinine, hs-CRP and other biochemical indicators were measured. The 1 937 community residents were divided into MS, high-risk and healthy control groups. Results There was a statistically significant positive correlation between hs-CRP level with age, TC, fasting glucose, uric acid, DBP, and a negative correlation was observed between hs-CRP and HDL-c levels (P ＜0. 001). Increasing numbers of the MS components resulted in higher serum levels of hs-CRP. Especially, baseline level of hs-CRP for those with 2 or more. Conclusions Serum level of hs-CRP is closely related to the component of metabolic syndrome.%目的 探讨血浆C反应蛋白水平与代谢综合征(MS)组分的相关性.方法 采用统一的流行病学调查表,由经过培训的调查员收集被试的人口统计学特征、疾病情况、行为生活方式等资料；对研究对象进行体格检查并采集空腹静脉血,实验室检测血糖、血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-c)、尿酸、肌酐、高敏C反应蛋白(hs-CRP)等生化指标.将1 937名社区中老年居民根据体检情况分为MS病例组、高危组和健康对照组,分析血浆hs-CRP与MS的相关性.结果 相关分析显示血浆hs-CRP水平与年龄、TC、空腹血糖、尿酸、舒张压(DBP)呈正相关,与HDL-c呈负相关(P＜0.001).偏相关分析进一步控制其他MS组分,血浆hs-CRP水平仍与年龄、TC、空腹血糖、尿酸、DBP呈正相关,与HDL-c呈负相关(P ＜0.001).随着MS组分聚集数量的增加,血浆hs-CRP水平呈现上升趋势(P=0.001).当MS组分≥2个时,中老年人群血浆hs-CRP水平明显升高(P＜0.05).结论 血浆hs-CRP与MS及其组分有关联.
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