银杏叶提取物对大鼠局灶性脑缺血-再灌注损伤的神经保护作用

摘要

Objective To investigate the protective effect of exlracl of Ginkgo biloba (EGB) on focal cerebral ischemia reperfusion (I/R ) injury in rats. Methods Wistar rats were randomly divided into sham, ischemia-reperfusion and treated by EGB groups. Rat middle cerebral I/R injury model was established with suture emholi method for 120 minutes. The neurobehavioral scores, neuron injure were evaluated at 24 hours of reperfusion. Results After 24 hours of reperfusion, EGB injection improved neurological outcome and reduced neuron injury. Conclusions EGB can have neuroprotection against I/R injury.%目的 研究银杏叶提取物(EGB)对大鼠局灶性脑缺血-再灌注损伤的神经保护作用机制.方法 采用改良线栓法建立大鼠大脑中动脉阻塞脑缺血-再灌往模型.实验动物随机分为假手术组、模型组、EGB治疗组.观察局灶性脑缺血2h再灌注24h后,大鼠神经行为学评分及神经元的变化.结果 再灌注24 h后,与单纯缺血-再灌注组相比,给予EGB溶液注射可以改善动物的神经行为学评分、减轻神元损伤.结论 EGB对大鼠局灶性脑缺血-再灌注损伤具有神经保护作用.