NEUROPROTECTIVE ACTION OF SOLUBLE URSODEOXYCHOLIC ACID IN MODELS OF FOCAL ISCHEMIA

摘要

FIELD: medicine.;SUBSTANCE: in order to reduce volume of ischemic stroke infarction, improve functional recovery, increase of eNOS expression, inhibit apoptosis and increase eNOS expression, treat symptoms of ischemic stroke or delivery of bile acid product to brain in patient after ischemic stroke or subjected to risk of ischemic stroke, composition which includes ursodeoxycholic acid, maltodextrin and water, is introduced. In said composition ursodeoxycholic acid and maltodextrin remain in solution at all values of solution pH in selected range from pH=1 to pH=10.;EFFECT: invention makes it possible to produce efficient impact on said states due to improved bioaccessibility of ursodeoxycholic acid to patient's brain.;8 cl, 2 tbl, 11 ex, 4 dwg