miR-126 rs4636297 G＞A 基因多态性与冠心病的相关性

摘要

Objective To investigate the relationship between the miR-126 rs4636297 G>A polymorphism and the risk for coronary artery disease in Southern Chinese population.Methods The genotypes of the miR-126 rs4636297 G>A polymorphism were determined in 563 coronary artery disease patients and 646 control blood donors by polymerase chain reaction-ligase detection reaction( PCR-LDR) .Associ-ation between the polymorphism and the risk for coronary artery disease was evaluated by unconditional logistic regression analysis.Results The frequency of AA,AG and GG genotypes in the case subjects were 2.1 %,22.6%and 75.3 % respectively and in the control subjects were 1.7%,25.4%and 72.9%.No significant difference was observed in the frequency of miR-126 rs4636297 genotypes between cases and controls(χ2=1.525,P=0.466).No significantly increased risk for coronary artery disease was observed for those carrying A variant allele (OR=0.92,95%CI=0.73~1.16,P=0.484).Conclusions miR-126 rs4636297 G>A polymorphism is not associated with coronary artery disease in Southern Chinese population.%目的：探讨 miR-126 rs4636297 G＞A 基因多态性与冠心病遗传易感的关系。方法利用聚合酶链式反应-连接酶检测反应（ PCR-LDR）分析技术，对563例冠心病患者和646例对照个体的miR-126 rs4636297 G＞A多态位点进行分型，采用非条件逻辑回归分析该多态位点与冠心病易感的相关性。结果 AA、AG、GG基因型在冠心病组中的分布频率分别为2.1％、22.6％和75.3％，在对照组中分别是1.7％、25.4％和72.9％，两组间基因型频率分布无统计学差异（χ2＝1.525，P＝0.466）。携带 miR-126 rs4636297 A变异等位基因与冠心病的遗传易感无明显相关性（OR＝0.92，95％CI＝0.73～1.16，P＝0.484）。结论 miR-126 rs4636297 G＞A多态位点与华南地区冠心病易感无相关性。