天津市塘沽社区老年人高尿酸血症患病率调查及相关因素分析

摘要

Objective To investigate the prevalence of hyperuricemia (HUA) in the elderly in Tanggu Community of Tianjin,and to analyze the related factors.Methods The elderly inhabitants from one community of Tanggu in Tianjin were randomly selected and their serum uric acid (SUA)levels and metabolic syndrome (MS)-related indexes were examined.There were 622 subjects with complete data (260 men,362 women; mean age 67.4 ± 6.0 years).Results The standardized prevalence of HUA in the elderly in this community was 9.1％ in total,and 7.6％ in males,10.6％ in females,and there was no significant difference between males and females (P=0.281).The levels of SUA were (283.37 ± 78.69) μmol/L in total,(315.80 ± 74.39) μmol/L in males and (260.00 ±73.31) μmol/L in females,and the SUA level was higher in males than in females (P＜0.001).The levels of blood urea,creatinine (Cr),triglyceride (TG),body mass index (BMI) were higher in patients with HUA than in patients with normal serum uric acid (P=0.000,0.000,0.002,0.049respectively).The multiple factors regression analysis showed that the SUA level was positively correlated with the levels of blood urea,Cr,TG,low density lipoprotein cholesterol (LDL-C) (P=0.000,0.017,0.000,0.019) and was negatively correlated with the levels of high density lipoprotein cholesterol (HDL-C) and fasting blood glucose (P=0.000,0.001).Conclusions The prevalence of HUA in the elderly is lower in Tanggu Community of Tianjin than in other cities in China.The SUA level of the elderly is significant higher in males than in females.The lower kidney function,hypertriglyceridemia and higher LDL-C are the risk factors for HUA,while elevated HDL-C and fasting blood glucose are associated with the decreased SUA level.%目的 了解天津市塘沽社区老年人的高尿酸血症(hyperuricemia)的患病情况,并分析影响血尿酸水平的相关因素. 方法 随机抽取天津市塘沽区某居民小区常住老年人进行尿酸和代谢综合征相关项目的检查.其中有完整资料者622例,平均年龄(67.4±6.0)岁,男性260例,女性362例. 结果 (1)该社区老年人高尿酸血症的标化患病率为9.1％,其中老年男性的标化患病率为7.6％,老年女性的标化患病率为10.6％,男女患病率比较差异无统计学意义(P=0.281)；老年尿酸的水平为(283.37±78.69)μmol/L,其中男性为(315.80±74.39) μmol/L,女性为(260.00±73.31)μmol/L,男性高于女性(P＜0.001)；(2)高尿酸血症组血尿素、肌酐、三酰甘油和体质指数高于正常尿酸组(P值分别为0.000、0.000、0.002、0.049)；(3)多因素回归分析显示尿酸与血尿素、肌酐、三酰甘油、低密度脂蛋白胆固醇(LDL-C)呈正相关(P值分别为0.000,0.017,0.000,0.019),尿酸与高密度脂蛋白胆固醇(HDL-C)和空腹血糖呈负相关(P值分别为0.000和0.001). 结论 (1)天津市塘沽社区老年人高尿酸血症的患病率低于我国其他城市和地区老年人的患病率.(2)老年男性尿酸的平均水平高于女性.(3)肾功能降低、三酰甘油和LDL-C升高是尿酸增高的危险因素,而HDL-C和空腹血糖水平升高是尿酸水平降低的因素.