河北任丘老年人高尿酸血症患病率及相关因素分析

摘要

Objective To investigate the prevalence of hyperuricemia (HUA)in Renqiu elderly residents in urban and rural areas,and to analyze the related factors.Methods A cluster random sampling method was used for study,the sample involved the age 60 to 70 years of Renqiu permanent residents including 5 010 cases screened object. Using face to face health questionnaires,anthropometric measurements,and laboratory test were performed.HUA and risk factors were analyzed using spearman correlation,multiple regression methods.Results The prevalence of HUA in the elderly in Renqiu was 6.1%,9.8% in males,3.2% in females,and there was significant difference between males and females(P <0.05 ).The multiple factors regression analysis showed that the uric acid level was positively correlated with waist circumference,TG,INS,diastolic blood pressure(P <0.05),but negatively correlated with TC,HDL-C,FPG,systolic blood pressure and heart rate(P <0.05).Conclusion The prevalence of HUA in the elderly is lower in Hebei Renqiu than in other areas in China,HUA was associated with the variety of cardiovascular disease risk factors.Waist circumference,TG,INS and diastolic blood pressure are the risk factors for HUA,while TC,HDL-C,FPG,systolic blood pressure and heart rate are associated with the decreased SUA level.%目的：了解河北省任丘市城乡老年人的高尿酸血症(HUA)患病情况，分析影响血尿酸水平的相关因素。方法采用整群随机抽样方法，选取任丘市城乡年龄60~70岁的常住居民为筛查对象，共计5010例，采取面对面健康问卷调查、人体测量、实验室检测。采用 Spearman 相关分析，尿酸多因素相关性采用多元回归分析。结果任丘老年人 HUA 的患病率为6.1%，其中老年男性 HUA 的患病率为9.8%，老年女性 HUA 的患病率为3.2%，男女患病率比较差异有统计学意义(P <0.05)。多元回归分析显示，尿酸与腰围、甘油三酯(TG)、胰岛素(INS)、舒张压呈正相关，尿酸与总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、收缩压、心率呈负相关。结论河北任丘地区老年人 HUA 患病率低于我国其他地区老年人患病率，与多种心脑血管疾病危险因素相关。腰围、TG、INS、舒张压升高是尿酸水平增高的危险因素，而 TC、HDL-C、FPG、收缩压、心率升高是尿酸水平降低的因素。