原发性帕金森病患者危险因素的病例对照研究

摘要

目的 分析与帕金森病(PD)发病相关的影响因素,为病因学研究和防治提供线索.方法 通过1∶4配对病例对照研究,对2010 2011年我院收治的91例PD患者和364例非PD患者进行问卷调查,通过条件Logistic回归分析与发病相关的影响因素. 结果 家族阳性史(OR=5.421,95％CI:1.272～23.103)、母亲孕期吸烟(OR=2.495,95％CI:1.044～5.961)、母亲怀孕年龄＞37岁(OR=1.607,95％ CI:1.224～2.112)、农村生活史＞l0年(OR=3.330,95％ CI:1.268～8.741)、饮酒史(OR=3.673,95％ CI:1.766～7.643)、不经常进行体力活动(OR=2.147,95％CI:1.279～3.602)是PD发病的危险因素. 结论 PD是遗传和环境因素综合作用发生的疾病,应有重点地对其相关危险因素进行干预.%Objective To analyze the possible risk factors for Parkinson's disease (PD),and to provide clues to its etiology and prevention.Methods A matched case-control study,including 91 cases of PD and 364 controls,was carried out in Shanxi Provincial People's Hospital.Subjects completed an interviewer administered questionnaire about some putative risk factors.Multivariable conditional Logistic regression model was used to analyze the associated factors for PD.SAS 8.0 was used to analyze the data.Results 6 risk factors were found significantly associated with PD.The odds ratio (OR) of Parkinson's disease was 5.421 (95％CI:1.272-23.103) for family history,3.330 (95％CI:1.268-8.741) for rural living more than 10 years,2.495 (95％CI:1.044-5.961) for maternal smoking during pregnancy,1.607 (95％ CI:1.224-2.112) for maternal age more than 37 years,3.673 (95％CI:1.766 7.643) for history of drinking alcohol,2.147 (95％CI:1.279 3.602) for less physical exercising.Conclusions PD is a disease affected by the interaction of genetic and environmental factors,and the risk factors should be intervened selectively.