Ghrelin/GHS-R激动剂和MTL/MTL-R激动剂r与胃肠动力关系的研究进展

摘要

Ghrelin and motilin (MTL) are mainly secreted by digestive tract,and they both can promote gastrointestinal motility. Disorder of gastrointestinal motility (DGIM)is a gastrointestinal motility or sensory disease mainly caused by neuroregulatory disorder,its main symptoms are nausea,vomiting,abdominal pain and abdominal distension. More and more studies have indicated that ghrelin,MTL and their receptor agonists are closely related to DGIM. This article reviewed the advances in studies on relationship between ghrelin/ GHS-R agonist,MTL/ MTL-R agonist and DGIM.%Ghrelin和胃动素(MTL)主要由消化道分泌,有促进胃肠道运动的作用.胃肠动力疾病(DGIM)是主要由神经支配调节障碍导致的胃肠动力或感觉性疾病,以恶心、呕吐、腹痛、腹胀为主要症状.越来越多研究表明,ghrelin、MTL及其受体激动剂与DGIM发生关系密切.本文就ghrelin/GHS-R激动剂和MTL/MTL-R激动剂与DGIM关系的研究进展作一综述.