目的 观察大麻素受体(CNR)在溃疡性结肠炎(UC)中的表达,探讨其作用及意义.方法 采用免疫组织化学方法检测45例UC患者和30例健康对照者肠道组织中CNR1和CNR2的表达,并进一步分析CNR1和CNR2与UC临床特征的关系.结果 CNR1和CNR2在UC患者中表达阳性率分别为62.2%、68.9%,明显高于正常对照组(26.7%、36.7%,P<0.05);CNR1和CNR2表达与UC疾病活动性明显相关(P<0.05),与UC严重程度、病变部位及临床特征无明显相关(P>0.05).结论 CNR在UC肠道组织中表达增加,而且与疾病活动性明显相关,提示CNR可能在UC发生、发展中发挥重要的作用.%Objective To investigate the expression and clinical significance of cannabinoid receptor (CNR) in intestinal tissue in patients with ulcerative colitis ( UC ) . Methods 45 UC patients and 30 normal controls were enrolled. Expression of CNR1 and CNR2 in UC intestinal tissue and normal controls were determined by immunohistochemical staining, and the relationship with clinical characteristics was analyzed. Results Expression positive rates of CNR1 and CNR2 in UC patients were 62. 2% and 68. 9% , significantly higher than the normal control (26. 7% , 36. 7% , P < 0.05) ; the expression of CNR1 and CNR2 were significantly related with disease activity in UC patients (P <0.05) , but not related with severity of disease, site of lesions and clinical characteristics (P >0. 05) . Conclusion Expression of CNR is high in UC patients, and is significant correlate with disease activity, which suggests that CNR may play an important role in the pathogenesis of UC.
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