急性胰腺炎患者凝血功能测定的临床价值

摘要

目的 探讨急性胰腺炎(AP)患者的凝血功能变化及其临床意义.方法 检测AP组和正常对照组(NC)的凝血功能指标:凝血酶原时间(PT)、凝血酶原时间国际标准化指数(INR)、部分活化凝血酶原时间(APTT)和纤维蛋白原浓度(FIB).结果 重型胰腺炎(SAP)患者与正常对照组、轻型胰腺炎(MAP)患者的凝血功能比较,差异具有统计学意义(P＜0.01)；MAP患者与NC组比较,差异无统计学意义(P＞0.05)；无多器官功能衰竭组与多器官功能衰竭组比较,PT、INR、APTT和FIB值差异具有统计学意义(P＜0.01).结论 凝血功能的测定在AP患者的疾病进程中,可用于了解患者的微循环障碍情况、判断患者的病情轻重、纠正患者的凝血功能、了解病情的演变和发展,为改善疾病的预后提供科学的依据.%Objective To investigate changes of blood coagulation function in patients with acute pancreatitis (AP) and its clinical significance. Methods Blood coagulation indices were detected in AP group and normal control group ( NC) : including prothrombin time ( PT) , prothrombin time international normalized ratio (INR) , activated partial thromboplastin time ( APTT) and fibrinogen ( FIB ) . Results Coagulation function was different in severe acute pancreatitis (SAP) group and normal control, mild acute pancreatitis (MAP) group, the difference was statistically significant (P<0. 01) ; there was no significant difference (P>0.05) between MAP group and NC group; PT, INR, APTT and FIB values were statistically significant (P<0.01) in no multiple organ syndrome (MODS) group and MODS group. Conclusion In the process of AP patients, the determination of coagulation function can be used to understand the patients ' microcirculation, judge the patients' condition, correction of coagulation function, understand the evolution and development of disease, and provide scientific basis for disease prognosis improvement.