胃黏膜病理与幽门螺杆菌和胃蛋白酶原的相关性分析

摘要

目的 探讨不同胃黏膜病理表现与幽门螺杆菌(Helicobacter pylori,H.pylori)、血清胃蛋白酶原的相关性.方法 收集复旦大学附属上海市第五人民医院2015年7月-2016年6月完成胃镜活检病理、H.pylori测定及胃蛋白酶原(pepsinogen, PG)检测的患者386例,并分析其相关性.结果 胃黏膜病理与H.pylori感染无显著相关性(R=-0.084,P=0.100);胃黏膜病理与胃蛋白酶原Ⅰ(PGⅠ)无显著相关性(R=-0.003,P=0.949),与PGⅡ呈正相关(R=0.258,P=0.000),与胃蛋白酶原比值(PGR)呈负相关(R=-0.194,P=0.000);H.pylori与PGⅠ无显著相关性(R=-0.033,P=0.522),与PGⅡ呈负相关(R=-0.173,P=0.001),与PGR无显著相关性(R=0.093,P=0.069).胃黏膜病理与癌胚抗原(CEA)呈正相关(R=0.146,P=0.004),与年龄无显著相关性(R=-0.004,P=0.930).结论 胃黏膜病理改变与H.pylori感染无显著相关性,与PGⅡ及CEA呈正相关,与PGR呈负相关,H.pylori与PGⅡ呈负相关,与PGR无相关性.%Objective To investigate the correlation of different gastric mucosal pathologic manifestations with Helicobacter pylori (H.pylori) and serum pepsinogen.Methods Three hundred and eighty-six patients who completed the endoscopy biopsy pathology, H.pylori pathology determination and pepsinogen (PG) detection were collected in the Fifth People''s Hospital of Shanghai, Fudan University from Jul.2015 to Jun.2016, and the correlation was analyzed.Results Gastric mucosal pathology was not associated with H.pylori infection (R=-0.084, P=0.100).Gastric mucosal pathology was not significantly correlated with pepsinogenⅠ (PGⅠ) (R=-0.003, P=0.949), but was positively correlated with PGⅡ (R=0.258, P=0.000) and negatively correlated with pepsinogen ratio (PGR) (R=-0.194, P=0.000).There was no significant correlation between H.pylori and PGⅠ (R=-0.033, P=0.522), but H.pylori was negatively correlated with PGⅡ (R=-0.173, P=0.001).Gastric mucosal pathology was positively correlated with CEA (R=0.146, P=0.004), but not correlated with age (R=-0.004, P=0.930).Conclusion Gastric mucosal pathological changes is not correlated with H.pylori infection, and positively correlated with PGⅡ and CEA, and negatively correlated with PGR, H.pylori is negatively correlated with PGⅡ, and not correlated with PGR.