血小板活化测定对行冠状动脉支架置入术后患者的抗血小板治疗的指导意义

摘要

Objective To study the guiding value of the determination of platelet activation function for antiplatelet therapy in patients after PCI. Methods 160 inpatients with acute myocardial infarction from 2012 October to 2013 May those who underwent percutaneous coronary intervention therapy successfully were randomly divided into monitoring group and control group with 80 cases in each. The patients of monitoring group were measured the platelet activation function on the 3 day and 1 weeks after surgery, and were adjusted the treatment plan of antiplatelet drugs. Results The severe hemorrhage (ICH) and acute stent thrombosis and other serious adverse reactions occurred in the monitoring group of patients were significantly lower than those in the control group. Conclusion Monitoring the platelet activation after PCI, and adjusting the antiplatelet drugs can signiifcantly reduce the risk of serious bleeding and thrombosis in acute coronary stent. It is worthy to be popularized in clinical.%目的：探讨血小板活化测定对行经皮冠状动脉介入治疗（PCI）术后患者的抗血小板治疗的指导价值。方法选取2012年10月至2013年5月本院行PCI术的160例急性心肌梗死患者，随机分为监测组和对照组，各80例。其中监测组患者在术后3天和术后1周连续2次测定血小板活化功能，并相应地调整抗血小板药物的治疗方案。结果监测组患者的严重出血（颅内出血）和急性支架内血栓形成等严重不良反应发生例数显著低于对照组患者。结论 PCI术后连续监测血小板活化功能，并相应地调整抗血小板用药能够显著降低严重出血的风险，降低急性冠状动脉支架内血栓形成的概率，值得在临床上推广应用。